Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice

Myeung Ju Kim; Kyeung Min Joo; Yoon Hee Chung; Yun Jung Lee; Jaehyup Kim; Bong Hee Lee; Dong Hoon Shin; Kyung Hoon Lee; Choong Ik Cha

doi:10.1016/S0006-8993(03)02950-0

Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice

Myeung Ju Kim, Kyeung Min Joo, Yoon Hee Chung, Yun Jung Lee, Jaehyup Kim, Bong Hee Lee, Dong Hoon Shin, Kyung Hoon Lee, Choong Ik Cha

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS^(-/-) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS^(-/-) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS^(-/-) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters.

Original language	English (US)
Pages (from-to)	233-240
Number of pages	8
Journal	Brain Research
Volume	978
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)02950-0
State	Published - Jul 18 2003
Externally published	Yes

Keywords

Cerebral cortex
Neuronal nitric oxide synthase (nNOS) knock-out(-/-) mice
Nitric oxide (NO)
Vasoactive intestinal peptide (VIP)

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(03)02950-0

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@article{c29245976eca4e178fdc75bd17ec7367,

title = "Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice",

abstract = "Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS(-/-) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS(-/-) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS(-/-) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters.",

keywords = "Cerebral cortex, Neuronal nitric oxide synthase (nNOS) knock-out(-/-) mice, Nitric oxide (NO), Vasoactive intestinal peptide (VIP)",

author = "Kim, {Myeung Ju} and Joo, {Kyeung Min} and Chung, {Yoon Hee} and Lee, {Yun Jung} and Jaehyup Kim and Lee, {Bong Hee} and Shin, {Dong Hoon} and Lee, {Kyung Hoon} and Cha, {Choong Ik}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2002-015-EP0107). This study was supported in part by year 2003 BK21 project for Medicine, Dentistry and Pharmacy.",

year = "2003",

month = jul,

day = "18",

doi = "10.1016/S0006-8993(03)02950-0",

language = "English (US)",

volume = "978",

pages = "233--240",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1-2",

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TY - JOUR

T1 - Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice

AU - Kim, Myeung Ju

AU - Joo, Kyeung Min

AU - Chung, Yoon Hee

AU - Lee, Yun Jung

AU - Kim, Jaehyup

AU - Lee, Bong Hee

AU - Shin, Dong Hoon

AU - Lee, Kyung Hoon

AU - Cha, Choong Ik

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2002-015-EP0107). This study was supported in part by year 2003 BK21 project for Medicine, Dentistry and Pharmacy.

PY - 2003/7/18

Y1 - 2003/7/18

N2 - Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS(-/-) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS(-/-) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS(-/-) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters.

AB - Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS(-/-) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS(-/-) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS(-/-) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters.

KW - Cerebral cortex

KW - Neuronal nitric oxide synthase (nNOS) knock-out(-/-) mice

KW - Nitric oxide (NO)

KW - Vasoactive intestinal peptide (VIP)

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U2 - 10.1016/S0006-8993(03)02950-0

DO - 10.1016/S0006-8993(03)02950-0

M3 - Article

C2 - 12834919

AN - SCOPUS:0038094471

SN - 0006-8993

VL - 978

SP - 233

EP - 240

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice

Abstract

Keywords

ASJC Scopus subject areas

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