Vascular Disease and the Skeleton

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter briefly relates the vital interplay between vascular biology and bone physiology as relevant to metabolic bone disease. It reviews data that highlight how prevalent vascular disease processes impair skeletal homeostatic mechanisms. Avascular necrosis (AVN), or osteonecrosis, represents the best-recognized clinical disorder of vascular disease and the skeleton. Demer, Tintut, and colleagues recently demonstrated that multiple oxylipids derived from LDL-a key contributor to atherosclerosis and arteriosclerosis-suppresses osteoblastmediated bone formation, enhances T-cell receptor activator of nuclear factor-kappa B ligand (RANKL) production, and impairs skeletal anabolic responses to PTH. The perspectives of experts in endocrinology, cardiology, developmental biology, orthopedics, biochemistry, genetics, pathology, engineering and hematology often emphasize different features of the relationship between the vasculature and bone. This integrated picture provides a "toolbox" for devising novel strategies to address unmet needs in skeletal health.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Subtitle of host publicationEighth Edition
Number of pages6
ISBN (Electronic)9781118453926
ISBN (Print)9781118453889
StatePublished - Jul 19 2013


  • Arteriosclerosis
  • Atherosclerosis
  • Avascular necrosis (AVN)
  • Skeleton
  • Vascular disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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