Vascular biology and bone formation: Hints from HIF

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


In this issue of the JCI, Wang, Clemens, and colleagues demonstrate that hypoxia-inducible factor α (HIFα) signaling in bone-building osteoblasts is central to the coupling of angiogenesis and long bone development in mice (see the related article beginning on page 1616). They show that bone formation controlled by osteoblast HIFα signaling is not cell autonomous but is coupled to skeletal angiogenesis dependent upon VEGF signaling. Thus, strategies that promote HIFα signaling in osteoblasts may augment bone formation and accelerate fracture repair.

Original languageEnglish (US)
Pages (from-to)1477-1480
Number of pages4
JournalJournal of Clinical Investigation
Issue number6
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Medicine(all)


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