Variants of human papillomavirus type 16 predispose toward persistent infection

Lei Zhang, Hong Liao, Binlie Yang, Christopher P. Geffre, Ai Zhang, Aizhi Zhou, Huimin Cao, Jieru Wang, Zhenbo Zhang, Wenxin Zheng

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A cohort study of 292 Chinese women was conducted to determine the relationship between human papillomavirus (HPV) type 16 variants and persistent viral infection. Enrolled patients were HPV16 positive and had both normal cytology and histology. Flow-through hybridization and gene chip technology was used to identify the HPV type. A PCR sequencing assay was performed to find HPV16 E2, E6 and E7 gene variants. The associations between these variants and HPV16 persistent infection was analyzed by Fisher's exact test. It was found that the variants T178G, T350G and A442C in the E6 gene, as well as C3158A and G3248A variants in the E2 gene were associated with persistent HPV16 infection. No link was observed between E7 variants and persistent viral infection. Our findings suggest that detection of specific HPV variants would help identify patients who are at high risk for viral persistence and development of cervical neoplasia.

Original languageEnglish (US)
Pages (from-to)8453-8459
Number of pages7
JournalInternational Journal of Clinical and Experimental Pathology
Issue number7
StatePublished - 2015


  • Human papillomavirus
  • Persistent infection
  • Variants

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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