We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).
|Original language||English (US)|
|Number of pages||3|
|State||Published - Aug 2009|
ASJC Scopus subject areas