Abstract
We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension.
Original language | English (US) |
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Pages (from-to) | 232-234 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2014 |
Keywords
- C-H cyanation
- Oxidative Strecker reaction
- Primary amine
- Schiff base ligand
- Vanadium catalyst
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry