Valdecoxib for the management of chronic and acute pain

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Cyclooxygenase-2 specific inhibitors have anti-inflammatory and analgesic properties, and are effective in managing a wide range of chronic and acute painful conditions such as adult rheumatoid arthritis, osteoarthritis, migraine, primary dysmenorrhea and postoperative pain. Valdecoxib, an orally administered cyclooxygenase-2 specific inhibitor, provides effective pain relief for both chronic and acute conditions, and reduces postoperative opioid use, with a concomitant reduction in opioid-related adverse events. Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events. This drug profile reviews the efficacy, safety and tolerability of valdecoxib for the management of chronic and acute pain.

Original languageEnglish (US)
Pages (from-to)11-24
Number of pages14
JournalExpert review of neurotherapeutics
Issue number1
StatePublished - Jan 2005


  • Cyclooxygenase-2 specific inhibitor
  • Nonsteroidal anti-inflammatory drugs
  • Opioid-sparing
  • Osteoarthritis
  • Pain
  • Postoperative
  • Primary dysmenorrhea
  • Rheumatoid arthritis
  • Valdecoxib

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)


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