Vacuoles

C. J. Stefan; W. M. Henne; S. D. Emr

doi:10.1016/B978-0-12-378630-2.00441-2

Vacuoles

C. J. Stefan, W. M. Henne, S. D. Emr

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Vacuoles and their mammalian counterparts, lysosomes, are membrane-bound cytoplasmic organelles that contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most notably, this organelle is an important site for the degradation of cellular lipids, membrane-associated proteins, and cytoplasmic proteins. In addition to its degradative functions, the vacuole/lysosome plays important roles in pH and ion homeostasis, nutrient storage, protein quality control, the innate immune pathway, and stress signaling responses. Accordingly, mis-regulation of lysosomal function has been implicated in several aspects of human disease, including neurodegenerative diseases.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	331-336
Number of pages	6
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00441-2
State	Published - Feb 15 2013

Keywords

Autophagy
Contractile vacuole
Endocytosis
Endosomal sorting complexes required for transport (ESCRT) pathway
Endosome
Hydrolase
Lysosomal storage disease
Lysosome
Lysosome-related organelle
Multivesicular body
Pathogen-containing vacuole
V-ATPase

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/B978-0-12-378630-2.00441-2

Cite this

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title = "Vacuoles",

abstract = "Vacuoles and their mammalian counterparts, lysosomes, are membrane-bound cytoplasmic organelles that contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most notably, this organelle is an important site for the degradation of cellular lipids, membrane-associated proteins, and cytoplasmic proteins. In addition to its degradative functions, the vacuole/lysosome plays important roles in pH and ion homeostasis, nutrient storage, protein quality control, the innate immune pathway, and stress signaling responses. Accordingly, mis-regulation of lysosomal function has been implicated in several aspects of human disease, including neurodegenerative diseases.",

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doi = "10.1016/B978-0-12-378630-2.00441-2",

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AU - Stefan, C. J.

AU - Henne, W. M.

AU - Emr, S. D.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Vacuoles and their mammalian counterparts, lysosomes, are membrane-bound cytoplasmic organelles that contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most notably, this organelle is an important site for the degradation of cellular lipids, membrane-associated proteins, and cytoplasmic proteins. In addition to its degradative functions, the vacuole/lysosome plays important roles in pH and ion homeostasis, nutrient storage, protein quality control, the innate immune pathway, and stress signaling responses. Accordingly, mis-regulation of lysosomal function has been implicated in several aspects of human disease, including neurodegenerative diseases.

AB - Vacuoles and their mammalian counterparts, lysosomes, are membrane-bound cytoplasmic organelles that contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most notably, this organelle is an important site for the degradation of cellular lipids, membrane-associated proteins, and cytoplasmic proteins. In addition to its degradative functions, the vacuole/lysosome plays important roles in pH and ion homeostasis, nutrient storage, protein quality control, the innate immune pathway, and stress signaling responses. Accordingly, mis-regulation of lysosomal function has been implicated in several aspects of human disease, including neurodegenerative diseases.

KW - Autophagy

KW - Contractile vacuole

KW - Endocytosis

KW - Endosomal sorting complexes required for transport (ESCRT) pathway

KW - Endosome

KW - Hydrolase

KW - Lysosomal storage disease

KW - Lysosome

KW - Lysosome-related organelle

KW - Multivesicular body

KW - Pathogen-containing vacuole

KW - V-ATPase

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DO - 10.1016/B978-0-12-378630-2.00441-2

M3 - Chapter

AN - SCOPUS:85042768674

SN - 9780123786302

SP - 331

EP - 336

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc.

ER -

Vacuoles

Abstract

Keywords

ASJC Scopus subject areas

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