C. J. Stefan, W. M. Henne, S. D. Emr

Research output: Chapter in Book/Report/Conference proceedingChapter


Vacuoles and their mammalian counterparts, lysosomes, are membrane-bound cytoplasmic organelles that contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most notably, this organelle is an important site for the degradation of cellular lipids, membrane-associated proteins, and cytoplasmic proteins. In addition to its degradative functions, the vacuole/lysosome plays important roles in pH and ion homeostasis, nutrient storage, protein quality control, the innate immune pathway, and stress signaling responses. Accordingly, mis-regulation of lysosomal function has been implicated in several aspects of human disease, including neurodegenerative diseases.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
StatePublished - Feb 15 2013


  • Autophagy
  • Contractile vacuole
  • Endocytosis
  • Endosomal sorting complexes required for transport (ESCRT) pathway
  • Endosome
  • Hydrolase
  • Lysosomal storage disease
  • Lysosome
  • Lysosome-related organelle
  • Multivesicular body
  • Pathogen-containing vacuole
  • V-ATPase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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