Vacuolar proton pumps

Dennis K. Stone; Bill P. Crider; Thomas C. Südhof; Xiao Song Xie

doi:10.1007/BF00808116

Vacuolar proton pumps

Dennis K. Stone, Bill P. Crider, Thomas C. Südhof, Xiao Song Xie

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F₁F₀-type proton pumps of mitochondria

Original language	English (US)
Pages (from-to)	605-620
Number of pages	16
Journal	Journal of Bioenergetics and Biomembranes
Volume	21
Issue number	5
DOIs	https://doi.org/10.1007/BF00808116
State	Published - Oct 1989

Keywords

Proton-translocating ATPase
evolution
organelle acidification

ASJC Scopus subject areas

Physiology
Cell Biology

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10.1007/BF00808116

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title = "Vacuolar proton pumps",

abstract = "Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria",

keywords = "Proton-translocating ATPase, evolution, organelle acidification",

author = "Stone, {Dennis K.} and Crider, {Bill P.} and S{\"u}dhof, {Thomas C.} and Xie, {Xiao Song}",

year = "1989",

month = oct,

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language = "English (US)",

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journal = "Journal of Bioenergetics and Biomembranes",

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AU - Stone, Dennis K.

AU - Crider, Bill P.

AU - Südhof, Thomas C.

AU - Xie, Xiao Song

PY - 1989/10

Y1 - 1989/10

N2 - Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria

AB - Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria

KW - Proton-translocating ATPase

KW - evolution

KW - organelle acidification

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JO - Journal of Bioenergetics and Biomembranes

JF - Journal of Bioenergetics and Biomembranes

IS - 5

ER -

Vacuolar proton pumps

Abstract

Keywords

ASJC Scopus subject areas

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