Vacuolar proton pumps

Dennis K. Stone, Bill P. Crider, Thomas C. Südhof, Xiao Song Xie

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria

Original languageEnglish (US)
Pages (from-to)605-620
Number of pages16
JournalJournal of Bioenergetics and Biomembranes
Issue number5
StatePublished - Oct 1989


  • Proton-translocating ATPase
  • evolution
  • organelle acidification

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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