Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

Niraj C. Patel, Paula M. Hertel, Mary K. Estes, Maite De La Morena, Ann M. Petru, Lenora M. Noroski, Paula A. Revell, I. Celine Hanson, Mary E. Paul, Howard M. Rosenblatt, Stuart L. Abramson

Research output: Contribution to journalArticlepeer-review

174 Scopus citations


Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalNew England Journal of Medicine
Issue number4
StatePublished - Jan 28 2010

ASJC Scopus subject areas

  • Medicine(all)


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