Utilization of omeprazole to augment subtherapeutic voriconazole concentrations for treatment of aspergillus infections

Natalie K. Boyd; Cindy L. Zoellner; Mark A. Swancutt; Kavita P. Bhavan

doi:10.1128/AAC.00700-12

Utilization of omeprazole to augment subtherapeutic voriconazole concentrations for treatment of aspergillus infections

Natalie K. Boyd, Cindy L. Zoellner, Mark A. Swancutt, Kavita P. Bhavan

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Voriconazole is the preferred antifungal agent for Aspergillus infections. Therapeutic drug monitoring is recommended to achieve target concentrations and prevent toxicity. However, variable pharmacokinetics, cytochrome P450 polymorphisms, and extensive drug-drug interactions can contribute to subtherapeutic concentrations. We report a voriconazole "boosting" effect of omeprazole to achieve target concentrations for the treatment of Aspergillus in a patient who had persistently subtherapeutic trough concentrations.

Original language	English (US)
Pages (from-to)	6001-6002
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	56
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00700-12
State	Published - Nov 2012

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Voriconazole is the preferred antifungal agent for Aspergillus infections. Therapeutic drug monitoring is recommended to achieve target concentrations and prevent toxicity. However, variable pharmacokinetics, cytochrome P450 polymorphisms, and extensive drug-drug interactions can contribute to subtherapeutic concentrations. We report a voriconazole {"}boosting{"} effect of omeprazole to achieve target concentrations for the treatment of Aspergillus in a patient who had persistently subtherapeutic trough concentrations.",

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AU - Bhavan, Kavita P.

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AB - Voriconazole is the preferred antifungal agent for Aspergillus infections. Therapeutic drug monitoring is recommended to achieve target concentrations and prevent toxicity. However, variable pharmacokinetics, cytochrome P450 polymorphisms, and extensive drug-drug interactions can contribute to subtherapeutic concentrations. We report a voriconazole "boosting" effect of omeprazole to achieve target concentrations for the treatment of Aspergillus in a patient who had persistently subtherapeutic trough concentrations.

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Utilization of omeprazole to augment subtherapeutic voriconazole concentrations for treatment of aspergillus infections

Abstract

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