TY - JOUR
T1 - Use of reiterative selection for defining protein-nucleic acid interactions
AU - Ouellette, Michel M.
AU - Wright, Woodring E.
N1 - Funding Information:
The authors would like to acknowledge all the scientistsw ho have contributed to the body of knowledge contained in this review. It was impossiblet o recognize all important contributions and we make our apologies to those scientistsw e have not cited. The work from the WE Wright’s laboratory was supported by the NIH (AG01228). MM Ouellete was a recipient of a fellowship from the Medical Research Council of Canada. We also wish to thank Karen Farmer for reviewing the manuscript.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Nucleic acids not only code for proteins, but also play a role in a multitude of biological processes, where they act as structural supports, binding sites, co-factors, or catalysts. Recently, an array of techniques has been developed in which molecules that are best fit to perform a given task are selected from a pool of randomized RNA or DNA molecules. These techniques can provide information about the structure/function relationship governing the various biochemical properties of RNA and DNA, including their interaction with proteins. Immediate applications are found not only in the field of transcriptional regulation, but also in the field of RNA-based catalysis.
AB - Nucleic acids not only code for proteins, but also play a role in a multitude of biological processes, where they act as structural supports, binding sites, co-factors, or catalysts. Recently, an array of techniques has been developed in which molecules that are best fit to perform a given task are selected from a pool of randomized RNA or DNA molecules. These techniques can provide information about the structure/function relationship governing the various biochemical properties of RNA and DNA, including their interaction with proteins. Immediate applications are found not only in the field of transcriptional regulation, but also in the field of RNA-based catalysis.
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U2 - 10.1016/0958-1669(95)80011-5
DO - 10.1016/0958-1669(95)80011-5
M3 - Article
C2 - 7534505
AN - SCOPUS:0028947957
SN - 0958-1669
VL - 6
SP - 65
EP - 72
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 1
ER -