Use of dMLC for implementation of dynamic respiratory-gated radiation therapy

Eric W. Pepin, Huanmei Wu, Hiroki Shirato

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose: To simulate and evaluate the use of dynamic multileaf collimators (dMLC) in respiratory gating to compensate for baseline drift. Methods: Tumor motion tracking data from 30 lung tumors over 322 treatment fractions was analyzed with the finite state model. A dynamic respiratory gating window was established in real-time by determining the average positions during the previous two end-of-expiration breathing phases and centering the dMLC aperture on a weighted average of these positions. A simulated dMLC with physical motion constraints was used in dynamic gating treatment simulations. Fluence maps were created to provide a statistical description of radiation delivery for each fraction. Duty cycle was also calculated for each fraction. Results: The average duty cycle was 2.3% greater under dynamic gating conditions. Dynamic gating also showed higher fluences and less tumor obstruction. Additionally, dynamic gating required fewer beam toggles and each delivery period was longer on average than with static gating. Conclusions: The use of dynamic gating showed better performance than static gating and the physical constraints of a dMLC were shown to not be an impediment to dynamic gating.

Original languageEnglish (US)
Article number101708
JournalMedical physics
Issue number10
StatePublished - 2013
Externally publishedYes


  • Baseline shift
  • Lung cancer
  • Respiratory gating
  • Respiratory motion

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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