Use of Biologic Agents in Extremity Reconstruction

Andrew E. Grush, Monal Depani, Matthew J. Parham, Valeria Mejia-Martinez, Alexandra Thornton, Douglas M. Sammer

Research output: Contribution to journalArticlepeer-review


Skin and soft tissue defects of the lower extremity present a unique challenge for the reconstructive surgeon. Successful repair of the lower extremity relies not only on strong anatomical knowledge and surgical expertise, but also on careful consideration of the numerous preoperative factors and indications that may alter the patient’s response to operative management. While many of these injuries result from burns, avulsive trauma, diabetes, or vascular insufficiencies, a significant portion can be associated with resection of neoplastic pathologies. This review outlines the uses, indications, and considerations for biologic wound agents in reconstructing skin and soft tissue defects of the lower extremity following Mohs micrographic surgery.

Original languageEnglish (US)
JournalSeminars in Plastic Surgery
StateAccepted/In press - 2022


  • cutaneous malignancies
  • fasciocutaneous flap
  • integra
  • lower extremity
  • melanoma
  • Mohs micrographic surgery

ASJC Scopus subject areas

  • Surgery


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