Abstract
PURPOSE: The purpose of this study was to study the use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography (F-18 FDG PET) for monitoring therapeutic response by rhabdomyosarcoma (RMSA) in children. PATIENTS AND METHODS: A retrospective case study was performed by searching a computer database for the patients with RMSA in whom F-18 FDG PET studies were performed pre- and posttreatment. The data of the PET studies from these patients were analyzed in conjunction with clinical treatment and other imaging studies to determine whether interval changes of F-18 FDG uptake by the RMSA reflect response of RMSA to treatment. RESULTS: Four patients with RMSA who received both pretreatment and posttreatment F-18 FDG PET studies were identified from the database and included in this study. A dramatic decrease of F-18 FDG uptake by the tumor was evident in the patients who had a favorable response to the therapy and prolonged remission of the disease. In contrast, persistent abnormal FDG uptake in one patient was associated with early relapse of the RMSA. CONCLUSIONS: F-18 FDG PET may be useful for monitoring therapeutic response by RMSA in children, which needs to be verified with a prospective study in a larger patient population.
Original language | English (US) |
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Pages (from-to) | 394-397 |
Number of pages | 4 |
Journal | Clinical nuclear medicine |
Volume | 31 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2006 |
Keywords
- 2-deoxy-2-[F-18]-fluoro-D-glucose
- Pediatrics
- Positron emission tomography
- Rhabdomyosarcoma
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging