TY - JOUR
T1 - Upper and Lower Extremity Measurement of Tissue Sodium and Fat Content in Patients with Lipedema
AU - Crescenzi, Rachelle
AU - Donahue, Paula M.C.
AU - Petersen, Kalen J.
AU - Garza, Maria
AU - Patel, Niral
AU - Lee, Chelsea
AU - Beckman, Joshua A.
AU - Donahue, Manus J.
N1 - Funding Information:
Imaging experiments were performed in the Vanderbilt Human Imaging Core, using research resources supported by the National Institutes of Health (NIH) grant 1S10OD021771‐01 and the Institutional National Research Service Award (NRSA) T32 EB001628. Recruitment through www.ResearchMatch.org is supported by the National Center for Advancing Translational Sciences (NCATS) Clinical Translational Science Award (CTSA) Program, award number 5UL1TR002243‐03. Funding was provided by the Lipedema Foundation (LF) Postdoctoral Research Fellowship, LF Collaborative Grant #12, and the NIH/NINR 1R01NR015079. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. .
Publisher Copyright:
© 2020 The Obesity Society
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Objective: The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). Methods: MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30.3 ± 4.4 kg/m2) and controls without lipedema (n = 14, age = 42.8 ± 13.2 years, BMI = 28.8 ± 4.4 kg/m2). Participants were assessed for pain and disease stage. Sodium MRI was performed in the forearm and calf to quantify regional tissue sodium content (TSC, mmol/L). Chemical-shift–encoded water-fat MRI was performed in identical regions for measurement of fat/water (ratio). Results: In the calf, skin TSC (16.3 ± 2.6 vs. 14.4 ± 2.2 mmol/L, P = 0.04), muscle TSC (20.3 ± 3.0 vs. 18.3 ± 1.7 mmol/L, P = 0.03), and fat/water (1.03 ± 0.37 vs. 0.56 ± 0.21 ratio, P < 0.001) were significantly higher in participants with lipedema versus control participants. In the forearm, skin TSC (13.4 ± 3.3 vs. 12.0 ± 2.3 mmol/L, P = 0.2, Cohen’s d = 0.50) and fat/water (0.65 ± 0.24 vs. 0.48 ± 0.24 ratio, P = 0.07, Cohen’s d = 0.68) demonstrated moderate effect sizes in participants with lipedema versus control participants. Calf skin TSC was significantly correlated with pain (Spearman’s rho = 0.55, P = 0.03) and disease stage (Spearman’s rho = 0.82, P < 0.001) among participants with lipedema. Conclusions: MRI-measured tissue sodium and fat content are significantly higher in the lower extremities, but not upper extremities, of patients with lipedema compared with BMI-matched controls.
AB - Objective: The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). Methods: MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30.3 ± 4.4 kg/m2) and controls without lipedema (n = 14, age = 42.8 ± 13.2 years, BMI = 28.8 ± 4.4 kg/m2). Participants were assessed for pain and disease stage. Sodium MRI was performed in the forearm and calf to quantify regional tissue sodium content (TSC, mmol/L). Chemical-shift–encoded water-fat MRI was performed in identical regions for measurement of fat/water (ratio). Results: In the calf, skin TSC (16.3 ± 2.6 vs. 14.4 ± 2.2 mmol/L, P = 0.04), muscle TSC (20.3 ± 3.0 vs. 18.3 ± 1.7 mmol/L, P = 0.03), and fat/water (1.03 ± 0.37 vs. 0.56 ± 0.21 ratio, P < 0.001) were significantly higher in participants with lipedema versus control participants. In the forearm, skin TSC (13.4 ± 3.3 vs. 12.0 ± 2.3 mmol/L, P = 0.2, Cohen’s d = 0.50) and fat/water (0.65 ± 0.24 vs. 0.48 ± 0.24 ratio, P = 0.07, Cohen’s d = 0.68) demonstrated moderate effect sizes in participants with lipedema versus control participants. Calf skin TSC was significantly correlated with pain (Spearman’s rho = 0.55, P = 0.03) and disease stage (Spearman’s rho = 0.82, P < 0.001) among participants with lipedema. Conclusions: MRI-measured tissue sodium and fat content are significantly higher in the lower extremities, but not upper extremities, of patients with lipedema compared with BMI-matched controls.
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U2 - 10.1002/oby.22778
DO - 10.1002/oby.22778
M3 - Article
C2 - 32270924
AN - SCOPUS:85083070148
SN - 1930-7381
VL - 28
SP - 907
EP - 915
JO - Obesity
JF - Obesity
IS - 5
ER -