Unusual expression of CD94 on CD8+ TCR-αβ T cells in infectious mononucleosis

Yongsheng Ren, L. Jeffrey Medeiros, Hesham M. Amin, Michael E. Rytting, Jeffrey L. Jorgensen, Weina Chen

Research output: Contribution to journalArticlepeer-review


Infectious mononucleosis, caused by primary Epstein-Barr virus (EBV) infection, is usually a benign, self-limited lymphoproliferative disorder. We report a case of a 21-year-old woman who presented with fever, sore throat, severe neutropenia, and absolute lymphocytosis with atypical lymphocytes. In situ hybridization for EBV-encoded small RNA performed on the marrow aspirate clot specimen demonstrated scattered positive cells. EBV serology was compatible with primary infection. Flow cytometry immunophenotypic studies performed on aspirate material revealed a profoundly expanded population of CD8+ T-cell receptor (TCR)-αβ T cells with uniform expression of CD94. No evidence of a monoclonal T-cell population was found as assessed by Vβ use with flow cytometry and by TCR γ-chain gene rearrangement using a polymerase chain reaction method. Uniform expression of CD94 in an exuberant reactive proliferation of CD8+ TCR-αβ T cells in infectious mononucleosis has not been reported previously, and combined with atypical morphology might be misinterpreted as a malignant neoplasm.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalAnnals of Diagnostic Pathology
Issue number1
StatePublished - Feb 1 2007


  • CD94
  • Immunophenotype
  • Infectious mononucleosis
  • NK cell receptors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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