Mice that lack a maternally transmitted antigen (Mta) on the cell surface share a distinctive type of mitochondrial DNA. This 1s evident from restriction analyses of mitochondrial DMAs from 25 strains of mice whose antigenic state 1s known. One hundred sixty-eight cleavage sites have been mapped 1n the mitochondrial DNA of Mta mice. Detailed maps for the 8 other types of mitochondrial DNA detected 1n the survey have also been prepared. The Mta mice are estimated to differ from those expressing the antigen by 108 to 141 base substitutions at widely scattered points 1n the mitochondrial genome.
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