TY - JOUR
T1 - Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta
T2 - The Obstructive Descending Aorta in HLHS
AU - de Vecchi, Adelaide
AU - Faraci, Alessandro
AU - Fernandes, Joao Filipe
AU - Marlevi, David
AU - Bellsham-Revell, Hannah
AU - Hussain, Tarique
AU - Laji, Nidhin
AU - Ruijsink, Bram
AU - Wong, James
AU - Razavi, Reza
AU - Anderson, David
AU - Salih, Caner
AU - Pushparajah, Kuberan
AU - Nordsletten, David
AU - Lamata, Pablo
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/10
Y1 - 2022/10
N2 - Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].
AB - Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].
KW - 4D flow
KW - Aorta
KW - Conduit function
KW - Hypoplastic left heart syndrome
KW - Reservoir function
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U2 - 10.1007/s12265-022-10221-4
DO - 10.1007/s12265-022-10221-4
M3 - Article
C2 - 35199256
AN - SCOPUS:85125085361
SN - 1937-5387
VL - 15
SP - 1075
EP - 1085
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 5
ER -