Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer

Ruth Sacks; Jennie Y. Law; Hong Zhu; Muhammad S. Beg; David E. Gerber; Baran D. Sumer; Larry L. Myers; John M. Truelson; Lucien Nedzi; David Sher; Randall S. Hughes; Saad A. Khan

doi:10.1159/000504651

Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer

Ruth Sacks, Jennie Y. Law, Hong Zhu, Muhammad S. Beg, David E. Gerber, Baran D. Sumer, Larry L. Myers, John M. Truelson, Lucien Nedzi, David Sher, Randall S. Hughes, Saad A. Khan

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Recurrence time and metastatic sites in HPV+ HNSCC (Group 1) were compared to patients with HPV-negative/unknown cancers arising in the hypopharynx, larynx, or glottis (Group 2) as well as to patients with HPV-negative/unknown cancers in theoral cavity, oropharynx, hard palate, or tonsil (Group 3). Results: 7/109 (6.4%) patients with HPV+ HNSCC developed DM. The median time to metastases was 11 months. At a median follow-up of 18-25 months, there was no difference in the overall rate of DM for the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.21) and Group 3 (HPV-/unknown) (p = 0.13). There was a significant difference in the rate of DM to the lung in the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.012) and Group 3 (HPV-/unknown) (p = 0.002). Conclusions: There was no observed difference in the time to development of DM between the HPV-/unknown and HPV+ HNSCC groups. However, the HPV+ HNSCC group showed a higher rate of DM to the lung compared to the HPV-/unknown -HNSCC group (p = 0.002).

Original language	English (US)
Pages (from-to)	179-185
Number of pages	7
Journal	Oncology (Switzerland)
Volume	98
Issue number	3
DOIs	https://doi.org/10.1159/000504651
State	Published - Feb 1 2020

Keywords

Distant metastases
HPV positivity
Head and neck cancer

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1159/000504651

Cite this

@article{af0bd829b04c4d3a858f97f70c55e5dd,

title = "Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer",

abstract = "Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Recurrence time and metastatic sites in HPV+ HNSCC (Group 1) were compared to patients with HPV-negative/unknown cancers arising in the hypopharynx, larynx, or glottis (Group 2) as well as to patients with HPV-negative/unknown cancers in theoral cavity, oropharynx, hard palate, or tonsil (Group 3). Results: 7/109 (6.4%) patients with HPV+ HNSCC developed DM. The median time to metastases was 11 months. At a median follow-up of 18-25 months, there was no difference in the overall rate of DM for the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.21) and Group 3 (HPV-/unknown) (p = 0.13). There was a significant difference in the rate of DM to the lung in the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.012) and Group 3 (HPV-/unknown) (p = 0.002). Conclusions: There was no observed difference in the time to development of DM between the HPV-/unknown and HPV+ HNSCC groups. However, the HPV+ HNSCC group showed a higher rate of DM to the lung compared to the HPV-/unknown -HNSCC group (p = 0.002).",

keywords = "Distant metastases, HPV positivity, Head and neck cancer",

author = "Ruth Sacks and Law, {Jennie Y.} and Hong Zhu and Beg, {Muhammad S.} and Gerber, {David E.} and Sumer, {Baran D.} and Myers, {Larry L.} and Truelson, {John M.} and Lucien Nedzi and David Sher and Hughes, {Randall S.} and Khan, {Saad A.}",

note = "Publisher Copyright: {\textcopyright} 2019 {\textcopyright} 2019 S. Karger AG, Basel.",

year = "2020",

month = feb,

day = "1",

doi = "10.1159/000504651",

language = "English (US)",

volume = "98",

pages = "179--185",

journal = "Oncology (Switzerland)",

issn = "0030-2414",

publisher = "UBM Medica Healthcare Publications",

number = "3",

}

TY - JOUR

T1 - Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer

AU - Sacks, Ruth

AU - Law, Jennie Y.

AU - Zhu, Hong

AU - Beg, Muhammad S.

AU - Gerber, David E.

AU - Sumer, Baran D.

AU - Myers, Larry L.

AU - Truelson, John M.

AU - Nedzi, Lucien

AU - Sher, David

AU - Hughes, Randall S.

AU - Khan, Saad A.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Recurrence time and metastatic sites in HPV+ HNSCC (Group 1) were compared to patients with HPV-negative/unknown cancers arising in the hypopharynx, larynx, or glottis (Group 2) as well as to patients with HPV-negative/unknown cancers in theoral cavity, oropharynx, hard palate, or tonsil (Group 3). Results: 7/109 (6.4%) patients with HPV+ HNSCC developed DM. The median time to metastases was 11 months. At a median follow-up of 18-25 months, there was no difference in the overall rate of DM for the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.21) and Group 3 (HPV-/unknown) (p = 0.13). There was a significant difference in the rate of DM to the lung in the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.012) and Group 3 (HPV-/unknown) (p = 0.002). Conclusions: There was no observed difference in the time to development of DM between the HPV-/unknown and HPV+ HNSCC groups. However, the HPV+ HNSCC group showed a higher rate of DM to the lung compared to the HPV-/unknown -HNSCC group (p = 0.002).

AB - Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Recurrence time and metastatic sites in HPV+ HNSCC (Group 1) were compared to patients with HPV-negative/unknown cancers arising in the hypopharynx, larynx, or glottis (Group 2) as well as to patients with HPV-negative/unknown cancers in theoral cavity, oropharynx, hard palate, or tonsil (Group 3). Results: 7/109 (6.4%) patients with HPV+ HNSCC developed DM. The median time to metastases was 11 months. At a median follow-up of 18-25 months, there was no difference in the overall rate of DM for the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.21) and Group 3 (HPV-/unknown) (p = 0.13). There was a significant difference in the rate of DM to the lung in the HPV+ HNSCC group compared to Group 2 (HPV-/unknown) (p = 0.012) and Group 3 (HPV-/unknown) (p = 0.002). Conclusions: There was no observed difference in the time to development of DM between the HPV-/unknown and HPV+ HNSCC groups. However, the HPV+ HNSCC group showed a higher rate of DM to the lung compared to the HPV-/unknown -HNSCC group (p = 0.002).

KW - Distant metastases

KW - HPV positivity

KW - Head and neck cancer

UR - http://www.scopus.com/inward/record.url?scp=85077186587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077186587&partnerID=8YFLogxK

U2 - 10.1159/000504651

DO - 10.1159/000504651

M3 - Article

C2 - 31846962

AN - SCOPUS:85077186587

SN - 0030-2414

VL - 98

SP - 179

EP - 185

JO - Oncology (Switzerland)

JF - Oncology (Switzerland)

IS - 3

ER -

Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this