Undermining the endothelium by ablation of MAPK-MEF2 signaling

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29 Scopus citations


Numerous stimuli activate Big MAPK-1 (BMK1), an MAPK that activates the myocyte enhancer factor-2 (MEF2) transcription factor. Conditional gene deletion showed BMK1 to be required for survival of endothelial cells (see the related article beginning on page 1138). An active form of MEF2C could partially bypass the requirement for BMK1 for endothelial cell survival in vitro. These findings reveal an essential role for BMK1-MEF2 signaling in an endothelial cell survival pathway and raise interesting questions about the molecular basis of this response.

Original languageEnglish (US)
Pages (from-to)1110-1112
Number of pages3
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Medicine(all)


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