Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, Jin Billy Li

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.

Original languageEnglish (US)
Article number107656
JournalCell Reports
Issue number7
StatePublished - May 19 2020
Externally publishedYes


  • A-to-I RNA editing
  • ADAR
  • BioID
  • BirA
  • DZF-domain
  • ILF2
  • ILF3
  • ZFR

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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