@article{9d49660e73534da6be934a1121cbd6c1,
title = "Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome",
abstract = "Background: Studies have begun to investigate the complex relationship between host and microorganisms in non-infectious pathologies such as acne, atopic dermatitis and psoriasis. Though the skin is exposed to environmental stressors such as ultraviolet radiation (UVR), no studies exist examining the effects of both UVA and UVB on the skin microbiome. Objective: To test the effect of UVA and UVB on human skin microbiome. Methods: To test whether UV will alter the cutaneous microbiome, participants were exposed to doses of UVA (22-47 J/cm2) or UVB (100-350 mJ/cm2) and samples were collected. DNA was isolated and sequenced to identify the microbial composition of each sample. Results: There was vast intra- and inter-subject variation at all time points, and phylum and species-level differences were identified. These included an increase in the phylum Cyanobacteria and a decrease in the family Lactobacillaceae and Pseudomonadaceae. The sensitivity of microbes to UVR and their re-colonization potential following exposure differed in UVA vs UVB samples. Limitations: The sample size was small, and the study was limited to males. Conclusion: The results demonstrate that UVR has profound qualitative and quantitative influences on the composition of the skin microbiome, possibly effecting skin pathology in which UVR is a factor.",
keywords = "microbiome, skin, ultraviolet radiation",
author = "Burns, {Erin M.} and Hana Ahmed and Isedeh, {Prescilia N.} and Indermeet Kohli and {Van Der Pol}, William and Abdullah Shaheen and Muzaffar, {Anum F.} and Camli Al-Sadek and Foy, {Thompson M.} and Abdelgawwad, {Mohammad S.} and Sumeira Huda and Lim, {Henry W.} and Iltefat Hamzavi and Sejong Bae and Morrow, {Casey D.} and Elmets, {Craig A.} and Nabiha Yusuf",
note = "Funding Information: Award Number: P30AR050948; NIH Cancer Prevention and Control Training Grant, Grant/Award Number: R25 CA47888; University of Alabama at Birmingham; National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/ Award Number: 1R01AR071157-01A1; NIH; UAB Comprehensive Cancer Center, Grant/Award Number: P30 CA013148 and UL1TR001417 Funding Information: This work was partially supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR071157-01A1 and UAB IMPACT funds to NY, Pilot & Feasibility Study to CDM from NIH funded UAB Skin Disease Research Center grant P30AR050948 and NIH Cancer Prevention and Control Training Grant R25 CA47888 to EMB. The following are acknowledged for their support of the Microbiome Resource at the University of Alabama at Birmingham: School of Medicine, Comprehensive Cancer Center (P30 CA013148), Center for Clinical Translational Science (UL1TR001417), Microbiome Center and Heflin Center for Genomic Sciences. We acknowledge assistance with bioinformatics analysis by Ranjit Kumar and Travis Ptacek. Funding Information: This work was partially supported by the National Institute of Funding Information: Arthritis and Musculoskeletal and Skin Diseases 1R01AR071157-01A1 and UAB IMPACT funds to NY, Pilot & Feasibility Study to CDM from NIH funded UAB Skin Disease Research Center grant P30AR050948 and NIH Cancer Prevention and Control Training Grant R25 CA47888 to EMB. The following are acknowledged for their support of the Microbiome Resource at the University of Alabama at Birmingham: School of Medicine, Comprehensive Cancer Center (P30 CA013148), Center for Clinical Translational Science (UL1TR001417), Microbiome Center and Heflin Center for Genomic Sciences. We acknowledge assistance with bioinformatics analysis by Ranjit Kumar and Travis Ptacek. Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2019",
month = feb,
doi = "10.1111/exd.13854",
language = "English (US)",
volume = "28",
pages = "136--141",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "2",
}