TY - GEN
T1 - Ultrasound therapy amplifies chemotherapeutic effectiveness in head and neck cancer
AU - Sorace, Anna G.
AU - Knowles, Joseph
AU - Heath, Cara
AU - Rosenthal, Eben
AU - Hoyt, Kenneth
PY - 2012
Y1 - 2012
N2 - Microbubble (MB) mediated ultrasound (US) therapy is a novel technique to non-invasively enhance cancer treatment by increasing cell membrane permeability and vascular extravasation. The objective of this experiment is to determine if MB-mediated US therapy can improve cancer therapy, specifically cisplatin or cetuximab, in head and neck cancer. In vitro experiments included combination chemotherapy and MB-mediated US therapy on head and neck cancer cell line, SCC-5, and dose curve responses to therapy. In vivo experimentation included a four week study of MB-mediated US therapy compared to current standard therapy of drug alone. Monitoring of tumor response to therapy included caliper measurements, diffusion-weighted magnetic resonance (DW-MR) imaging, and immunohistologic analysis. Anti-tumor effects increased by over 50% when combining MB-mediated US therapy with cetuximab and cisplatin (P = 0.01, P = 0.02). MB-mediated US therapy was seen to produce as additive effect by increasing localized delivery of drug in head and neck cancer. This technique shows potential for improved localized therapy in cancer.
AB - Microbubble (MB) mediated ultrasound (US) therapy is a novel technique to non-invasively enhance cancer treatment by increasing cell membrane permeability and vascular extravasation. The objective of this experiment is to determine if MB-mediated US therapy can improve cancer therapy, specifically cisplatin or cetuximab, in head and neck cancer. In vitro experiments included combination chemotherapy and MB-mediated US therapy on head and neck cancer cell line, SCC-5, and dose curve responses to therapy. In vivo experimentation included a four week study of MB-mediated US therapy compared to current standard therapy of drug alone. Monitoring of tumor response to therapy included caliper measurements, diffusion-weighted magnetic resonance (DW-MR) imaging, and immunohistologic analysis. Anti-tumor effects increased by over 50% when combining MB-mediated US therapy with cetuximab and cisplatin (P = 0.01, P = 0.02). MB-mediated US therapy was seen to produce as additive effect by increasing localized delivery of drug in head and neck cancer. This technique shows potential for improved localized therapy in cancer.
UR - http://www.scopus.com/inward/record.url?scp=84882422258&partnerID=8YFLogxK
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U2 - 10.1109/ULTSYM.2012.0107
DO - 10.1109/ULTSYM.2012.0107
M3 - Conference contribution
AN - SCOPUS:84882422258
SN - 9781467345613
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 433
EP - 435
BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012
T2 - 2012 IEEE International Ultrasonics Symposium, IUS 2012
Y2 - 7 October 2012 through 10 October 2012
ER -