Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

Fangyuan Xiong; Mouna Xiong; Sabnis Nirupama; Shashank Sirsi; Andras Lacko; Kenneth Hoyt

doi:10.1109/ULTSYM.2017.8092380

Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

Fangyuan Xiong, Mouna Xiong, Sabnis Nirupama, Shashank Sirsi, Andras Lacko, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to tumor cells via their overexpressed SR-B1 receptor. The goal of this study is to investigate the potential of noninvasive US therapy to further improve delivery and tumor uptake of rHDL NPs preloaded with an infrared dye (IR780), which is devoted to the establishment of a surrogate chemotherapeutic model with optical localization.

Original language	English (US)
Title of host publication	2017 IEEE International Ultrasonics Symposium, IUS 2017
Publisher	IEEE Computer Society
ISBN (Electronic)	9781538633830
DOIs	https://doi.org/10.1109/ULTSYM.2017.8092380
State	Published - Oct 31 2017
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: Sep 6 2017 → Sep 9 2017

Other

Other	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	9/6/17 → 9/9/17

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2017.8092380

Cite this

Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake. / Xiong, Fangyuan; Xiong, Mouna; Nirupama, Sabnis et al.
2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8092380.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xiong, F, Xiong, M, Nirupama, S, Sirsi, S, Lacko, A & Hoyt, K 2017, Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8092380, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 9/6/17. https://doi.org/10.1109/ULTSYM.2017.8092380

@inproceedings{7efcd26e7f1d486eb96c9de369ec015f,

title = "Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake",

abstract = "The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to tumor cells via their overexpressed SR-B1 receptor. The goal of this study is to investigate the potential of noninvasive US therapy to further improve delivery and tumor uptake of rHDL NPs preloaded with an infrared dye (IR780), which is devoted to the establishment of a surrogate chemotherapeutic model with optical localization.",

author = "Fangyuan Xiong and Mouna Xiong and Sabnis Nirupama and Shashank Sirsi and Andras Lacko and Kenneth Hoyt",

year = "2017",

month = oct,

day = "31",

doi = "10.1109/ULTSYM.2017.8092380",

language = "English (US)",

booktitle = "2017 IEEE International Ultrasonics Symposium, IUS 2017",

publisher = "IEEE Computer Society",

note = "2017 IEEE International Ultrasonics Symposium, IUS 2017 ; Conference date: 06-09-2017 Through 09-09-2017",

}

TY - GEN

T1 - Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles

T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017

AU - Xiong, Fangyuan

AU - Xiong, Mouna

AU - Nirupama, Sabnis

AU - Sirsi, Shashank

AU - Lacko, Andras

AU - Hoyt, Kenneth

PY - 2017/10/31

Y1 - 2017/10/31

N2 - The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to tumor cells via their overexpressed SR-B1 receptor. The goal of this study is to investigate the potential of noninvasive US therapy to further improve delivery and tumor uptake of rHDL NPs preloaded with an infrared dye (IR780), which is devoted to the establishment of a surrogate chemotherapeutic model with optical localization.

AB - The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to tumor cells via their overexpressed SR-B1 receptor. The goal of this study is to investigate the potential of noninvasive US therapy to further improve delivery and tumor uptake of rHDL NPs preloaded with an infrared dye (IR780), which is devoted to the establishment of a surrogate chemotherapeutic model with optical localization.

UR - http://www.scopus.com/inward/record.url?scp=85039453087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039453087&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2017.8092380

DO - 10.1109/ULTSYM.2017.8092380

M3 - Conference contribution

AN - SCOPUS:85039453087

BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017

PB - IEEE Computer Society

Y2 - 6 September 2017 through 9 September 2017

ER -

Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

Abstract

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this