Abstract
We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in reflection mode. The system used intense acoustic bursts and a chargecoupled device (CCD) camera-based speckle contrast detection method. In addition, the implementation allows placing the tissue sample below (not within) an acoustic coupling water tank and scanning the tissue without moving the sample. Thus, the UOT system is more clinically applicable than previous transmission-mode systems. Furthermore, we have successfully imaged an ex vivo methyleneblue-dyed sentinel lymph node (SLN) embedded at a depth of 13 mm in chicken breast tissue. This UOT system offers several advantages: noninvasiveness, nonionizing radiation, portability, cost effectiveness, and the possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT system is mapping SLNs in axillary staging for breast cancer patients.
| Original language | English (US) |
|---|---|
| Article number | 024015 |
| Journal | Journal of biomedical optics |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2009 |
Keywords
- Axillary lymph node dissection
- Breast cancer
- Reflection-mode ultrasound-modulated optical tomography (UOT)
- Ring-shaped light illumination
- Sentinel lymph node (SLN) biopsy
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering