ULK1 targets Beclin-1 in autophagy

Volodymyr Y. Nazarko, Qing Zhong

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.

Original languageEnglish (US)
Pages (from-to)727-728
Number of pages2
JournalNature cell biology
Issue number7
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Cell Biology


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