Ubiquitin signalling in the NF-κB pathway

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492 Scopus citations


The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-κB pathway: degradation of IκB (inhibitor of NF-κB), processing of NF-κB precursors, and activation of the IκB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.

Original languageEnglish (US)
Pages (from-to)758-765
Number of pages8
JournalNature cell biology
Issue number8
StatePublished - Aug 2005

ASJC Scopus subject areas

  • Cell Biology


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