TY - JOUR
T1 - Type I interferons and T helper development
AU - Farrar, J. David
AU - Murphy, Kenneth M.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.
AB - Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.
UR - http://www.scopus.com/inward/record.url?scp=0033782944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033782944&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(00)01710-2
DO - 10.1016/S0167-5699(00)01710-2
M3 - Comment/debate
C2 - 11071526
AN - SCOPUS:0033782944
SN - 1471-4906
VL - 21
SP - 484
EP - 489
JO - Trends in Immunology
JF - Trends in Immunology
IS - 10
ER -