Alcohols were replaced by a two-carbon nitrile unit in good to excellent yields via dehydrative alkylation with (phenylsulfonyl)acetonitrile under modified Mitsunobu conditions followed by desulfonylation using magnesium. Diols and haloalcohols furnished cycloalkylnitriles.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 7 1995|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery