Two-carbon elongation/annulation of alcohols to nitriles

Jing Yu Lai, Jurong Yu, R. David Hawkins, J R Falck

Research output: Contribution to journalArticlepeer-review


Alcohols were replaced by a two-carbon nitrile unit in good to excellent yields via dehydrative alkylation with (phenylsulfonyl)acetonitrile under modified Mitsunobu conditions followed by desulfonylation using magnesium. Diols and haloalcohols furnished cycloalkylnitriles.

Original languageEnglish (US)
Pages (from-to)5691-5694
Number of pages4
JournalTetrahedron Letters
Issue number32
StatePublished - Aug 7 1995

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


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