Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land; Luis F. Parada; Robert A. Weinberg

doi:10.1038/304596a0

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land, Luis F. Parada, Robert A. Weinberg

Developmental Biology

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Abstract

Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.

Original language	English (US)
Pages (from-to)	596-602
Number of pages	7
Journal	Nature
Volume	304
Issue number	5927
DOIs	https://doi.org/10.1038/304596a0
State	Published - 1983

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title = "Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes",

abstract = "Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.",

author = "Hartmut Land and Parada, {Luis F.} and Weinberg, {Robert A.}",

year = "1983",

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AU - Land, Hartmut

AU - Parada, Luis F.

AU - Weinberg, Robert A.

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N2 - Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.

AB - Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.

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JO - Nature

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Abstract

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