Tumor-Treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines

Medicine & Life Sciences

• Double-Stranded DNA Breaks 100%
• Ionizing Radiation 89%
• Non-Small Cell Lung Carcinoma 78%
• Down-Regulation 61%
• Cell Line 51%
• Neoplasms 28%
• Chromatids 16%
• DNA Repair 12%
• 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 9%
• Cell Proliferation 8%
• Combined Modality Therapy 8%
• Gene Expression 8%
• Interphase 7%
• Glioblastoma 6%
• Mitosis 6%
• S Phase 6%
• DNA Damage 5%
• Cell Cycle 5%
• Population 5%
• Cell Death 5%
• Radiation 5%
• Apoptosis 4%
• DNA 3%
• Genes 2%
• Therapeutics 2%