TY - JOUR
T1 - Triggers for genomic rearrangements
T2 - Insights into genomic, cellular and environmental influences
AU - Mani, Ram Shankar
AU - Chinnaiyan, Arul M.
N1 - Funding Information:
We apologize to those whose relevant research was not cited owing to space limitations. We thank K. Callahan for help in figure preparation and J. Lupski and S. Girirajan for insightful comments. R.S.M. is supported by the Stewart Rahr–PCF Young Investigator Award from the Prostate Cancer Foundation. A.M.C. is supported by the Doris Duke Charitable Foundation Clinical Scientist Award, a Burroughs Welcome Foundation Award in Clinical Translational Research and the Prostate Cancer Foundation. A.M.C. is an American Cancer Society Research Professor.
PY - 2010/12
Y1 - 2010/12
N2 - Genomic rearrangements are associated with many human genomic disorders, including cancers. It was previously thought that most genomic rearrangements formed randomly but emerging data suggest that many are nonrandom, cell type-, cell stage- and locus-specific events. Recent studies have revealed novel cellular mechanisms and environmental cues that influence genomic rearrangements. In this Review, we consider the multitude of influences on genomic rearrangements by grouping these influences into four categories: proximity of chromosomal regions in the nucleus, cellular stress, inappropriate DNA repair or recombination, and DNA sequence and chromatin features. The synergy of these triggers can poise a cell for rearrangements and here we aim to provide a conceptual framework for understanding the genesis of genomic rearrangements.
AB - Genomic rearrangements are associated with many human genomic disorders, including cancers. It was previously thought that most genomic rearrangements formed randomly but emerging data suggest that many are nonrandom, cell type-, cell stage- and locus-specific events. Recent studies have revealed novel cellular mechanisms and environmental cues that influence genomic rearrangements. In this Review, we consider the multitude of influences on genomic rearrangements by grouping these influences into four categories: proximity of chromosomal regions in the nucleus, cellular stress, inappropriate DNA repair or recombination, and DNA sequence and chromatin features. The synergy of these triggers can poise a cell for rearrangements and here we aim to provide a conceptual framework for understanding the genesis of genomic rearrangements.
UR - http://www.scopus.com/inward/record.url?scp=78549278708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78549278708&partnerID=8YFLogxK
U2 - 10.1038/nrg2883
DO - 10.1038/nrg2883
M3 - Review article
C2 - 21045868
AN - SCOPUS:78549278708
SN - 1471-0056
VL - 11
SP - 819
EP - 829
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 12
ER -