Treatment of Renal Stones: Cellulose Phosphate or Magnesium?

David A. Cook, Charles Y.c. Pak, Catherine S. Delea, Frederic C. Bartter

Research output: Contribution to journalLetterpeer-review


To the Editor: Pak et al. (N Engl J Med 290:175–180, 1974) reported that hypercalciuria could be corrected, and stone formation prevented, in patients with probable absorptive hypercalciuria by means of a low calcium diet and the administration of cellulose phosphate to inhibit calcium absorption. During the treatment periods with oral cellulose phosphate, patients were also given 234 to 350 mg of magnesium by mouth as magnesium chloride per day to prevent magnesium depletion. However, magnesium alone in these quantities is known to inhibit the formation of calcium oxalate stones. Complete cessation of urinary-stone passage occurred in two subjects with.

Original languageEnglish (US)
Pages (from-to)1034-1035
Number of pages2
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 7 1974

ASJC Scopus subject areas

  • Medicine(all)


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