Treatment of calcium urolithiasis with diphosphonate: Efficacy and hazards

H. G. Bone, J. E. Zerwekh, F. Britton, C. Y C Pak

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The effect of treatment of renal stone formation with 5 to 20 mg./kg. per day oral disodium ethane-1-hydroxy-1, 1-diphosphonate for up to 30 months was examined in 12 patients with active renal (calcium) stone disease. The over-all incidence of stone passage decreased from 17.8 stones per year per patient before treatment to 7.7 stones per year per patient during therapy. Of the 12 patients 7 passed fewer stones or no stones during treatment. However, the incidence of stone passage was not changed substantially by disodium ethane-1-hydroxy-1, 1-diphosphonate in 5 patients. Symptoms of muscle weakness and pain in the back, hips and shoulder occurred in 3 patients during treatment, 2 patients had an increase in serum alkaline phosphatase and 1 patient had a decrease in bone density. Although disodium ethane-1-hydroxy-1, 1-diphosphonate may be clinically useful to manage calcium urolithiasis in certain patients its over-all use is limited because of its ineffectiveness in some patients and owing to its potential to induce osteomalacia.

Original languageEnglish (US)
Pages (from-to)568-571
Number of pages4
JournalJournal of Urology
Issue number5
StatePublished - 1979

ASJC Scopus subject areas

  • Urology


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