Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: A preliminary study

J. M. Stapleton; M. J. Eckardt; P. Martin; B. Adinoff; L. Roehrich; G. Bone; D. Rubinow; M. Linnoila

doi:10.1300/J251v07n03_08

Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: A preliminary study

J. M. Stapleton, M. J. Eckardt, P. Martin, B. Adinoff, L. Roehrich, G. Bone, D. Rubinow, M. Linnoila

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Abstract

The chronic effects of fluvoxamine (200 mg per day for 4 weeks) were studied in ten alcoholic organic brain syndrome patients in a double-blind cross-over design. Complete neuropsychological evaluation was performed as well as measurement of neurochemical changes in CSF. Fluvoxamine produced a small but significant improvement in memory performance. An analysis of fluvoxamine minus placebo difference scores showed a significant correlation between memory functioning and CSF 5HIAA levels. Alcohol amnestic syndrome patients who had the highest blood levels of fluvoxamine demonstrated the largest changes in CSF 5HIAA and improvement in memory performance under fluvoxamine. These findings implicate a role of serotonergic mechanisms in alcoholic organic brain syndrome and suggest that with individual titration of the drag dose, fluvoxamine might be a clinically useful agent in the treatment of this syndrome.

Original language	English (US)
Pages (from-to)	47-51
Number of pages	5
Journal	Advances in Alcohol and Substance Abuse
Volume	7
Issue number	3-4
DOIs	https://doi.org/10.1300/J251v07n03_08
State	Published - Mar 1 1988

ASJC Scopus subject areas

Medicine (miscellaneous)

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title = "Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: A preliminary study",

abstract = "The chronic effects of fluvoxamine (200 mg per day for 4 weeks) were studied in ten alcoholic organic brain syndrome patients in a double-blind cross-over design. Complete neuropsychological evaluation was performed as well as measurement of neurochemical changes in CSF. Fluvoxamine produced a small but significant improvement in memory performance. An analysis of fluvoxamine minus placebo difference scores showed a significant correlation between memory functioning and CSF 5HIAA levels. Alcohol amnestic syndrome patients who had the highest blood levels of fluvoxamine demonstrated the largest changes in CSF 5HIAA and improvement in memory performance under fluvoxamine. These findings implicate a role of serotonergic mechanisms in alcoholic organic brain syndrome and suggest that with individual titration of the drag dose, fluvoxamine might be a clinically useful agent in the treatment of this syndrome.",

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AU - Stapleton, J. M.

AU - Eckardt, M. J.

AU - Martin, P.

AU - Adinoff, B.

AU - Roehrich, L.

AU - Bone, G.

AU - Rubinow, D.

AU - Linnoila, M.

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Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: A preliminary study

Abstract

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