TY - JOUR
T1 - Trastuzumab-Induced Cardiomyopathy
AU - Guglin, Maya
AU - Cutro, Raymond
AU - Mishkin, Joseph D.
PY - 2008/6
Y1 - 2008/6
N2 - Trastuzumab is a recombinant humanized monoclonal antibody used for the treatment of advanced breast cancer. It improves survival and increases response to chemotherapy. The major side effect of trastuzumab is cardiotoxicity manifesting as a reduction in left ventricular systolic function, either asymptomatic or with signs and symptoms of heart failure. Although reversible in most cases, cardiotoxicity frequently results in the discontinuation of trastuzumab. The objective of this review is to summarize facts about trastuzumab-induced cardiotoxicity and to highlight the areas of future investigations. We searched PubMed for trials involving trastuzumab used as an adjuvant therapy for breast cancer, including the metastatic breast cancer setting, and focused on cardiotoxicity.
AB - Trastuzumab is a recombinant humanized monoclonal antibody used for the treatment of advanced breast cancer. It improves survival and increases response to chemotherapy. The major side effect of trastuzumab is cardiotoxicity manifesting as a reduction in left ventricular systolic function, either asymptomatic or with signs and symptoms of heart failure. Although reversible in most cases, cardiotoxicity frequently results in the discontinuation of trastuzumab. The objective of this review is to summarize facts about trastuzumab-induced cardiotoxicity and to highlight the areas of future investigations. We searched PubMed for trials involving trastuzumab used as an adjuvant therapy for breast cancer, including the metastatic breast cancer setting, and focused on cardiotoxicity.
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U2 - 10.1016/j.cardfail.2008.02.002
DO - 10.1016/j.cardfail.2008.02.002
M3 - Review article
C2 - 18514938
AN - SCOPUS:44349121910
SN - 1071-9164
VL - 14
SP - 437
EP - 444
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 5
ER -