TY - JOUR
T1 - Translocation t(11;22) in esthesioneuroblastoma
AU - Whang-Peng, Jacqueline
AU - Freter, Carl E.
AU - Knutsen, Turid
AU - Nanfro, J. J.
AU - Gazdar, Adi
N1 - Funding Information:
The patient was a 22-year-old Caucasian male who presented with epitaxis, nasal stuffiness, and headaches in October 1982. On examination, a large polyploid lesion was found to extend from the superior nasal cavities into both maxillary sinuses. He underwent turbinectomy, septectomy, and bilateral Caldwell-Luc resection; all gross disease was removed from the maxillary sinuses and 5600 tad in 28 fractions were delivered locally. The patient was in complete remission until a metastatic lesion, clinically presenting as a swelling of the left anterior chest, was observed. Computed tomographic scan of the thorax revealed a 10 × 10 cm mass in the chest From the Medicine Branch and NCI/NavyM edical Oncology Branch. National Cancer Institute, National Institutes of Health, Bethesda, MD.
PY - 1987/11
Y1 - 1987/11
N2 - Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.
AB - Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.
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U2 - 10.1016/0165-4608(87)90043-4
DO - 10.1016/0165-4608(87)90043-4
M3 - Article
C2 - 3478125
AN - SCOPUS:0023197372
SN - 0165-4608
VL - 29
SP - 155
EP - 157
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -