Abstract
It is becoming apparent that control of protein synthesis by metabolites is more common than previously thought. Much of that control is exerted at the level of initiation of mRNA translation, orchestrated by upstream open reading frames (uORFs) and RNA secondary structure. S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in polyamine biosynthesis and both mammalian and plant AdoMetDCs are translationally regulated by uORFs in response to polyamine levels by distinct mechanisms.
Original language | English (US) |
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Pages (from-to) | 424-427 |
Number of pages | 4 |
Journal | Biochemical Society Transactions |
Volume | 31 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2003 |
Keywords
- Polyamine
- S-adenosylmethionine decarboxylase
- Translation initiation
- Upstream open reading frame
ASJC Scopus subject areas
- Biochemistry