Translational regulation of the plant S-adenosylmethionine decarboxylase

C. Hanfrey, M. Franceschetti, M. J. Mayer, C. Illingworth, K. Elliott, M. Collier, B. Thompson, B. Perry, A. J. Michael

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


It is becoming apparent that control of protein synthesis by metabolites is more common than previously thought. Much of that control is exerted at the level of initiation of mRNA translation, orchestrated by upstream open reading frames (uORFs) and RNA secondary structure. S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in polyamine biosynthesis and both mammalian and plant AdoMetDCs are translationally regulated by uORFs in response to polyamine levels by distinct mechanisms.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalBiochemical Society Transactions
Issue number2
StatePublished - Apr 2003


  • Polyamine
  • S-adenosylmethionine decarboxylase
  • Translation initiation
  • Upstream open reading frame

ASJC Scopus subject areas

  • Biochemistry


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