Abstract
Background: MicroRNAs have critical roles in T cell development under normal and stress conditions. Results: Increasing miR-185 levels attenuate T cell development via the targeting of Mzb1, Nfatc3, and Camk4. Conclusion: Elevations in miR-185 impair thymopoiesis at several developmental stages. Significance: miR-185 levels are reduced in 22q11.2 deletion syndrome patients and the identification of its gene targets is clinically informative.
Original language | English (US) |
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Pages (from-to) | 30752-30762 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 42 |
DOIs | |
State | Published - Oct 18 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology