TY - JOUR
T1 - Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues
AU - Drake, B. L.
AU - Head, J. R.
N1 - Funding Information:
This work was supported by a grant toJ.R.H, from the National Institutes of Health (NIH AI 25227). The authors would like to thank Deborah Bogue and Charles Kresge for their technical assistance, Drs Ian Trowbridge and Larry Guilbert for their gifts of antibodies, and Rosemary Bell for assistance with manuscript preparation.
PY - 1990
Y1 - 1990
N2 - The expression of the transferrin receptor (TR) was examined on murine trophoblast cells on days 6, 8 and 10 of gestation, using a monoclonal antibody visualized by indirect immuno-fluorescence on cryostat sections of the implant site. In the day 6 tissues, TR were observed on both the ectoplacental cone (EPC) and mural giant cell trophoblast populations, as well as on the embryonic ectoderm, anti-mesometrial decidual cells, uterine glandular epithelium and myometrium. By the 8th day of gestation, TR expression was weak, or undetectable on trophoblast giant cells (TGC), but remained strong on the proliferating cells of the EPC and embryo. In the definitive placenta (day 10), TR are expressed primarily on the differentiated labyrinthine trophoblast cells involved in the maternal-fetal transfer of iron.
AB - The expression of the transferrin receptor (TR) was examined on murine trophoblast cells on days 6, 8 and 10 of gestation, using a monoclonal antibody visualized by indirect immuno-fluorescence on cryostat sections of the implant site. In the day 6 tissues, TR were observed on both the ectoplacental cone (EPC) and mural giant cell trophoblast populations, as well as on the embryonic ectoderm, anti-mesometrial decidual cells, uterine glandular epithelium and myometrium. By the 8th day of gestation, TR expression was weak, or undetectable on trophoblast giant cells (TGC), but remained strong on the proliferating cells of the EPC and embryo. In the definitive placenta (day 10), TR are expressed primarily on the differentiated labyrinthine trophoblast cells involved in the maternal-fetal transfer of iron.
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U2 - 10.1016/S0143-4004(05)80199-7
DO - 10.1016/S0143-4004(05)80199-7
M3 - Article
C2 - 2290804
AN - SCOPUS:0025223776
SN - 0143-4004
VL - 11
SP - 535
EP - 547
JO - Placenta
JF - Placenta
IS - 6
ER -