TY - JOUR
T1 - Transcriptional control by PARP-1
T2 - chromatin modulation, enhancer-binding, coregulation, and insulation
AU - Kraus, W. Lee
N1 - Funding Information:
The author thanks Matthew Gamble, Kristine Frizzell, and Raga Krishnakumar for their critical comments and helpful suggestions. The author's laboratory is supported by funding from the National Institute of Diabetes, Digestive, and Kidney Disorders.
PY - 2008/6
Y1 - 2008/6
N2 - The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) polymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD+-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene-regulatory outcomes.
AB - The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) polymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD+-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene-regulatory outcomes.
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U2 - 10.1016/j.ceb.2008.03.006
DO - 10.1016/j.ceb.2008.03.006
M3 - Review article
C2 - 18450439
AN - SCOPUS:44649130038
SN - 0955-0674
VL - 20
SP - 294
EP - 302
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -