TY - JOUR
T1 - Transcriptional architecture of the mammalian circadian clock
AU - Takahashi, Joseph S.
N1 - Funding Information:
The author thanks three anonymous reviewers for their constructive comments. Apologies to those whose work was not cited owing to content and length constraints. The author thanks N. Koike and T.-K. Kim for critical contributions to the research presented here. This work was supported by the Howard Hughes Medical Institute and US National Institutes of Health (NIH) grants R01AG045795 (to J.S.T.) and R21MH107672 (to G. Konopka and J.S.T.).
Publisher Copyright:
© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling. The genomic targets of circadian clocks are pervasive and are intimately linked to the regulation of metabolism, cell growth and physiology.
AB - Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling. The genomic targets of circadian clocks are pervasive and are intimately linked to the regulation of metabolism, cell growth and physiology.
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U2 - 10.1038/nrg.2016.150
DO - 10.1038/nrg.2016.150
M3 - Review article
C2 - 27990019
AN - SCOPUS:85006325468
SN - 1471-0056
VL - 18
SP - 164
EP - 179
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 3
ER -