TY - JOUR
T1 - TRAF3
T2 - a new component of the TLR-signaling apparatus
AU - Hoebe, Kasper
AU - Beutler, Bruce
PY - 2006/5
Y1 - 2006/5
N2 - Toll-like receptors (TLRs) are key sensors of microbially derived molecules that, upon activation, provide a pathogen-specific inflammatory response, leading to an efficient eradication of microbial pathogens. An important question has been how TLRs can provide signaling diversity when challenged with genotypic and functionally distinct pathogens. Recently, two studies have shown that tumor-necrosis factor receptor-associated factor 3 (TRAF3) is an essential component of the TLR-signaling pathway, being a crucial regulator in the induction of TLR-specific inflammatory responses.
AB - Toll-like receptors (TLRs) are key sensors of microbially derived molecules that, upon activation, provide a pathogen-specific inflammatory response, leading to an efficient eradication of microbial pathogens. An important question has been how TLRs can provide signaling diversity when challenged with genotypic and functionally distinct pathogens. Recently, two studies have shown that tumor-necrosis factor receptor-associated factor 3 (TRAF3) is an essential component of the TLR-signaling pathway, being a crucial regulator in the induction of TLR-specific inflammatory responses.
UR - http://www.scopus.com/inward/record.url?scp=33646746802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646746802&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2006.03.008
DO - 10.1016/j.molmed.2006.03.008
M3 - Short survey
C2 - 16621716
AN - SCOPUS:33646746802
SN - 1471-4914
VL - 12
SP - 187
EP - 189
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 5
ER -