The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.
|Original language||English (US)|
|Number of pages||4|
|Journal||Pure and Applied Chemistry|
|State||Published - Mar 1996|
ASJC Scopus subject areas
- Chemical Engineering(all)