Towards the asymmetric synthesis of bryostatin 1

Jef De Brabander; Maurits Vandewalle

doi:10.1351/pac199668030715

Towards the asymmetric synthesis of bryostatin 1

Jef De Brabander, Maurits Vandewalle

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The construction of the fragments C₁-C₉ 3 and C₁₇-C₂₇ 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.

Original language	English (US)
Pages (from-to)	715-718
Number of pages	4
Journal	Pure and Applied Chemistry
Volume	68
Issue number	3
DOIs	https://doi.org/10.1351/pac199668030715
State	Published - Mar 1996

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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title = "Towards the asymmetric synthesis of bryostatin 1",

abstract = "The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the {"}chiron{"} approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.",

author = "{De Brabander}, Jef and Maurits Vandewalle",

note = "Funding Information: Acknowledgements. We thank the VJ{"}'0''a nd the {"}Ministerie voor Wetenschapsbeleid{"} for financial assistance to the laboratory.",

year = "1996",

month = mar,

doi = "10.1351/pac199668030715",

language = "English (US)",

volume = "68",

pages = "715--718",

journal = "Pure and Applied Chemistry",

issn = "0033-4545",

publisher = "IUPAC Secretariat",

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TY - JOUR

T1 - Towards the asymmetric synthesis of bryostatin 1

AU - De Brabander, Jef

AU - Vandewalle, Maurits

N1 - Funding Information: Acknowledgements. We thank the VJ"'0''a nd the "Ministerie voor Wetenschapsbeleid" for financial assistance to the laboratory.

PY - 1996/3

Y1 - 1996/3

N2 - The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.

AB - The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.

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U2 - 10.1351/pac199668030715

DO - 10.1351/pac199668030715

M3 - Article

AN - SCOPUS:0000746887

SN - 0033-4545

VL - 68

SP - 715

EP - 718

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

IS - 3

ER -

Towards the asymmetric synthesis of bryostatin 1

Abstract

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