Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy

S. M.Nashir Udden; Guem Hee Baek; Kamal Pandey; Chantal Vidal; Yulun Liu; Asal S. Rahimi; D. Nathan Kim; Chika R. Nwachukwu; Ram S. Mani; Prasanna G. Alluri

doi:10.1038/s41698-023-00348-1

Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy

S. M.Nashir Udden, Guem Hee Baek, Kamal Pandey, Chantal Vidal, Yulun Liu, Asal S. Rahimi, D. Nathan Kim, Chika R. Nwachukwu, Ram S. Mani, Prasanna G. Alluri

Research output: Contribution to journal › Article › peer-review

Abstract

Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.

Original language	English (US)
Article number	11
Journal	npj Precision Oncology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41698-023-00348-1
State	Published - Dec 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/s41698-023-00348-1

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title = "Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy",

abstract = "Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.",

author = "Udden, {S. M.Nashir} and Baek, {Guem Hee} and Kamal Pandey and Chantal Vidal and Yulun Liu and Rahimi, {Asal S.} and Kim, {D. Nathan} and Nwachukwu, {Chika R.} and Mani, {Ram S.} and Alluri, {Prasanna G.}",

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doi = "10.1038/s41698-023-00348-1",

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AU - Udden, S. M.Nashir

AU - Baek, Guem Hee

AU - Pandey, Kamal

AU - Vidal, Chantal

AU - Liu, Yulun

AU - Rahimi, Asal S.

AU - Kim, D. Nathan

AU - Nwachukwu, Chika R.

AU - Mani, Ram S.

AU - Alluri, Prasanna G.

PY - 2023/12

Y1 - 2023/12

N2 - Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.

AB - Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.

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Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy

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