@article{2ea2e67e27074ffeb75bf79af8110b97,
title = "Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy",
abstract = "Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.",
author = "Udden, {S. M.Nashir} and Baek, {Guem Hee} and Kamal Pandey and Chantal Vidal and Yulun Liu and Rahimi, {Asal S.} and Kim, {D. Nathan} and Nwachukwu, {Chika R.} and Mani, {Ram S.} and Alluri, {Prasanna G.}",
note = "Funding Information: This work was supported in part by the US Department of Defense Breast Cancer Research Program Breakthrough Award (W81XWH-21-1-0112) to PGA, US Department of Defense Breast Cancer Research Program Breakthrough Award (W81XWH-21-1-0114), NIH grant R01CA245294 and Cancer Prevention and Research Institute of Texas (CPRIT) grant RP190454 to R.S.M. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41698-023-00348-1",
language = "English (US)",
volume = "7",
journal = "npj Precision Oncology",
issn = "2397-768X",
publisher = "Springer Nature",
number = "1",
}