Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments

Jef De Brabander; Stephane Rosset; Gérald Bernardinelli

doi:10.1055/s-1997-5757

Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments

Jef De Brabander, Stephane Rosset, Gérald Bernardinelli

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.

Original language	English (US)
Pages (from-to)	824-826
Number of pages	3
Journal	Synlett
Volume	1997
Issue number	7
DOIs	https://doi.org/10.1055/s-1997-5757
State	Published - Jan 1 1997

ASJC Scopus subject areas

Organic Chemistry

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title = "Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments",

abstract = "A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.",

author = "{De Brabander}, Jef and Stephane Rosset and G{\'e}rald Bernardinelli",

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AU - Rosset, Stephane

AU - Bernardinelli, Gérald

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N2 - A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.

AB - A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.

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Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments

Abstract

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