Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

Bo Liu; Ying Han; David R. Corey; Thomas Kodadek

doi:10.1021/ja0164226

Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

Bo Liu, Ying Han, David R. Corey, Thomas Kodadek

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34 Scopus citations

Abstract

A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site.

Original language	English (US)
Pages (from-to)	1838-1839
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	124
Issue number	9
DOIs	https://doi.org/10.1021/ja0164226
State	Published - Mar 6 2002

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0164226

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abstract = "A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site.",

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AU - Han, Ying

AU - Corey, David R.

AU - Kodadek, Thomas

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AB - A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site.

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Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

Abstract

ASJC Scopus subject areas

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