Total synthesis and initial structure - Function analysis of the potent V-ATPase inhibitors salicylihalamide A and related compounds

Engineering & Materials Science

• Adenosine Triphosphatases 67%
• Nucleophiles 41%
• Enantiomers 34%
• Lead compounds 33%
• Dimers 30%
• Olefins 23%
• Cells 19%
• Sulfur 19%
• Brain 16%
• Derivatives 16%
• Oxygen 16%
• Carbon 15%

Medicine & Life Sciences

• salicylihalamide A 100%
• Adenosine Triphosphatases 40%
• Isocyanates 24%
• Biological Products 15%
• Alkenes 12%
• Vacuolar Proton-Translocating ATPases 11%
• Salicylates 10%
• Sulfur 9%
• Cytotoxins 8%
• Skeleton 8%
• Carbon 7%
• Action Potentials 7%
• Osteoporosis 7%
• Cultured Cells 6%
• Cattle 6%
• Oxygen 5%
• Phenotype 4%
• Brain 3%
• Neoplasms 2%

Chemical Compounds

• Isocyanate 40%
• Total Synthesis 34%
• Occurrence in Nature 33%
• Cytotoxin 28%
• Olefin Metathesis 24%
• Salicylate 24%
• Mammalian Cell 20%
• Absolute Configuration 18%
• Nucleophile 17%
• Enantiomer 15%
• Dioxygen 9%
• Carbon Atom 9%