Topical Review: Use of Fetal Tissue in Foot and Ankle Surgery

Andrew E. Hanselman, Trapper A J Lalli, Robert D. Santrock

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Fetal tissues are well known for their therapeutic potential. They contain numerous growth factors, cytokines, and matrix components that promote regeneration of tissues while downregulating inflammation and scar formation. As a result, use of these treatments has expanded over the previous 20 years throughout various surgical specialties, including orthopaedics. With improved methods of sterilization, processing, and storage, surgeons need to be informed about the potential benefits of fetal tissue in foot and ankle surgery. The aim of this review is to provide a brief historical background, basic anatomy and physiology, and a current review of the literature in regard to chronic wounds, diabetic foot ulcerations, plantar fasciitis, tendon repair, adhesion prevention, nerve repair, and bone healing. Levels of Evidence: Level V: Expert Opinion

Original languageEnglish (US)
Pages (from-to)297-304
Number of pages8
JournalFoot and Ankle Specialist
Issue number4
StatePublished - Aug 1 2015


  • amniotic membrane
  • chorionic membrane
  • fetal tissue
  • placenta
  • umbilical cord

ASJC Scopus subject areas

  • Surgery
  • Podiatry
  • Orthopedics and Sports Medicine


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